Predicting amyloid PET positivity using plasma p-tau181 and other blood-based biomarkers.

Hyuk Sung KwonEun-Hye LeeHyung-Ji KimSo-Hee ParkHyun-Hee ParkJee Hyang JeongSeong-Ho KohSeong Hye ChoiJae-Hong Lee

Published in: Alzheimer's & dementia (Amsterdam, Netherlands) (2023)

Plasma p-tau181 showed a high performance in determining Aβ-PET positivity. Adding plasma NfL and APOE ε4 status improved the model fit without significant improvement in AUC.

Keyphrases

computed tomography
pet ct
positron emission tomography
cerebrospinal fluid
high fat diet
adipose tissue
metabolic syndrome
skeletal muscle
insulin resistance