Suspicions regarding the genetic inheritance of acute lymphoblastic leukemia in patients with down syndrome.
Emir BehluliNexhibe NuhiiThomas LiehrGazmend TemajPublished in: Journal of mother and child (2022)
Children with Down syndrome (DS) are at markedly increased risk for acute lymphoblastic leukaemia (ALL). DS is caused by trisomy of chromosome 21 affecting approximately 1 in 732 newborns in the USA. ALL is the most common cancer in children and constitutes approximately 25% of cancer diagnoses among children under the age of 15. Different protocols for treatment and management of paediatric ALL are available; however, DS children with ALL (DS-ALL) have increased risk of therapy-related toxicity compared to those without DS. Herein, we summarize the available literature on inherited predisposition for ALL, and possibilities for molecular therapy and treatment for DS-ALL patients.
Keyphrases
- young adults
- acute lymphoblastic leukemia
- papillary thyroid
- systematic review
- end stage renal disease
- emergency department
- chronic kidney disease
- gene expression
- squamous cell carcinoma
- oxidative stress
- stem cells
- intensive care unit
- newly diagnosed
- acute myeloid leukemia
- dna methylation
- mitochondrial dna
- bone marrow
- mesenchymal stem cells
- preterm infants
- childhood cancer
- prognostic factors
- preterm birth
- respiratory failure
- patient reported outcomes
- replacement therapy