Population Pharmacokinetics of Magnesium Sulfate in Preeclampsia and Associated Factors.
Tatiana Xavier da CostaFrancine Johansson AzeredoMarcela Abbott Galvão UrurahyMiguel Adelino da Silva FilhoRand Randall MartinsAntonio Gouveia OliveiraPublished in: Drugs in R&D (2021)
The PK of MgSO4 in pregnant women with PE is significantly affected by creatinine and body weight. Pregnant women with PE and higher body weight have a higher V and, consequently, a lower elimination rate of MgSO4. Pregnant women with PE and a higher serum creatinine value show lower CL and, therefore, lower MgSO4 elimination rate.