Therapeutic Inhibition of Acid-Sensing Ion Channel 1a Recovers Heart Function After Ischemia-Reperfusion Injury.
Meredith A ReddSarah E ScheuerNatalie J SaezYusuke YoshikawaHan Sheng ChiuLing GaoMark HicksJeanette E VillanuevaYashutosh JoshiChun Yuen ChowGabriel Cuellar-PartidaJason N PeartLouise E See HoeXiaoli ChenYuliangzi SunJacky Y SuenRobert J HatchBen RolloDi XiaMubarak A H AlzubaidiSnezana MaljevicGregory A Quaife-RyanJames E HudsonEnzo R PorrelloMelanie Y WhiteStuart J CordwellJohn F FraserSteven PetrouMelissa E ReicheltWalter G ThomasGlenn F KingPeter S MacdonaldNathan J PalpantPublished in: Circulation (2021)
Our data provide compelling evidence for a novel pharmacologic strategy involving ASIC1a blockade as a cardioprotective therapy to improve the viability of hearts subjected to IRI.