Fibroblasts inhibit osteogenesis by regulating nuclear-cytoplasmic shuttling of YAP in mesenchymal stem cells and secreting DKK1.

Fei HuangGuozhen WeiHai WangYing ZhangWenbin LanYun XieGui Wu

Published in: Biological research (2024)

Our research revealed that fibroblasts could modulate the nuclear-cytoplasmic shuttling of YAP in MSCs, thereby inhibiting their osteoblast differentiation. Fibroblasts could also secrete DKK1, which inhibited calcium nodule formation at the late stage of osteogenesis.

Keyphrases

mesenchymal stem cells
extracellular matrix
umbilical cord
bone regeneration
bone marrow
signaling pathway
single cell
stem cells