IDH1/2 wildtype gliomas grade 2 and 3 with molecular glioblastoma-like profile have a distinct course of epilepsy compared to IDH1/2 wildtype glioblastomas.
Mark P van OpijnenC Mircea S TesileanuLinda DirvenPim B van der MeerMaarten M J WijnengaArnaud J P E VincentMarike L D BroekmanHendrikus J DubbinkJohan M KrosSjoerd G van DuinenMarion SmitsPim J FrenchMartin J van den BentMartin J B TaphoornJohan A F KoekkoekPublished in: Neuro-oncology (2022)
Although the incidence proportion of epilepsy during the entire disease course is similar, IDHwt hLGG patients show a significantly higher incidence of epilepsy before diagnosis and a significantly longer median time between first seizure and diagnosis compared to IDHwt glioblastoma patients, indicating a distinct clinical course.