Senescent cells in giant cell arteritis display an inflammatory phenotype participating in tissue injury via IL-6-dependent pathways.

Dimitris VeroutisOurania D ArgyropoulouAndreas V GoulesKonstantinos KambasDimitris Anastasios PalamidasKonstantinos EvangelouSophia HavakiAikaterini PolyzouDimitrios ValakosEvangelia XingiElli KaratzaKyriaki A BokiAlberto CavazzaChristos KittasDimitris ThanosCaterina RicordiChiara MarvisiFrancesco MuratoreElena GalliStefania CrociCarlo SalvaraniVassilis G GorgoulisAthanasios G Tzioufas

Published in: Annals of the rheumatic diseases (2023)

Senescent cells with inflammatory phenotype are present in GCA arteries and are associated with the tissue inflammatory bulk, suggesting a potential implication in disease pathogenesis.

Keyphrases

induced apoptosis
oxidative stress
cell cycle arrest
giant cell
signaling pathway
cell proliferation
climate change
pi k akt