Metformin attenuates the TLR4 inflammatory pathway in skeletal muscle of diabetic rats.
Leonardo Gomes PeixotoRenata Roland TeixeiraDanielle Diniz VilelaLara Naves BarbosaDouglas Carvalho CaixetaSimone Ramos DeconteFernanda de Assis de AraújoRobinson Sabino-SilvaFoued Salmen EspindolaPublished in: Acta diabetologica (2017)
In summary, the results indicate a relationship between muscular TLR4, p-AMPK and NF-κB content and insulin sensitivity. The study also highlights that in situations of insulin resistance, such as in diabetic subjects, metformin treatment may prevent attenuation of activation of the inflammatory pathway.