Examining the role of astrogliosis and JNK signaling in post-traumatic epilepsy.

Coulter N SmallAbeer DagraMelanie MartinezEric WilliamsBrandon Lucke-Wold

Published in: Egyptian journal of neurosurgery (2022)

Reactive astrocytes may have dysfunctional glutamate regulation causing an increase in phosphorylated JNK after kainic acid administration. Future studies exploring the effects of JNK inhibition on post-traumatic epilepsy are recommended.

Keyphrases

signaling pathway
cell death
induced apoptosis
temporal lobe epilepsy
endoplasmic reticulum stress
oxidative stress
case control