Integrated high-throughput analysis identifies super enhancers associated with chemoresistance in SCLC.

Jiarong BaoMan LiShumei LiangYunchu YangJingfang WuQingqing ZouShun FangSize ChenLinlang Guo

Published in: BMC medical genomics (2019)

We screened out SEs involved with drug resistance and evaluated the functions of FOXP1, IRF1, and SP1 in chemoresistance. Our findings established a large group of SEs associated with drug resistance in small cell lung cancer, revealed the drug resistance mechanisms of SEs, and provided insights into the clinical applications of SEs.

Keyphrases

small cell lung cancer
high throughput
single cell
regulatory t cells
dendritic cells
genome wide
gene expression
brain metastases
immune response