Mitochondria regulate TRPV4-mediated release of ATP.
Xun ZhangMatthew D LeeCharlotte BuckleyCalum WilsonJohn G McCarronPublished in: British journal of pharmacology (2021)
These results highlight a previously unknown role of mitochondria in shaping TRPV4-mediated Ca2+ signalling by facilitating ATP release. When mitochondria are depolarised, TRPV4-mediated release of ATP via pannexin channels activates plasma membrane purinergic receptors to trigger IP3 -evoked Ca2+ release.