Paracrine stimulation of perinatal lung functional and structural maturation by mesenchymal stem cells.
Janine ObendorfClaire FabianUlrich H ThomeMandy LaubePublished in: Stem cell research & therapy (2020)
The results demonstrate that MSC-CM strongly stimulated functional and structural maturation of the fetal lungs. These effects were at least partially mediated by the PI3-K/AKT and Rac1 signaling pathway. Thus, MSCs not only repair a deleterious tissue environment, but also target lung cellular immaturity itself.