Senolytic elimination of Cox2-expressing senescent cells inhibits the growth of premalignant pancreatic lesions.

Dror Kolodkin-GalLior RoitmanYossi OvadyaNarmen AzazmehBenjamin AssoulineYehuda SchlesingerRachel KalifaShaul HorwitzYonatan KhalatnikAnna Hochner-GerAshraf ImamJonathan Abraham DemmaEitan WinterHadar BenyaminiSharona ElgavishAreej As KhatibKaren MeirKarine AtlanEli PikarskyOren ParnasYuval DorGideon ZamirIttai Ben-Porath Valery Krizhanovsky

Published in: Gut (2021)

These findings reveal that senescent PanIN cells support tumour growth and progression, and provide a first indication that elimination of senescent cells may be effective as preventive therapy for the progression of precancerous lesions.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
signaling pathway
oxidative stress
gene expression
genome wide
dna methylation