Regulation of the deleterious effects of binge-like exposure to alcohol during adolescence by α7 nicotinic acetylcholine receptor agents: prevention by pretreatment with a α7 negative allosteric modulator and emulation by a α7 agonist in alcohol-preferring (P) male and female rats.

Zachary A RoddSheketha R HauserH Scott SwartzwelderR Aaron WaeissDebomoy K LahiriRichard L Bell

Published in: Psychopharmacology (2020)

The data indicate that α7 mediates the effects of alcohol during adolescence. The data also indicate that α7 NAMs are potential prophylactic agents to reduce the deleterious effects of adolescent alcohol abuse.

Keyphrases

alcohol consumption
depressive symptoms
electronic health record
young adults
big data
small molecule
machine learning
artificial intelligence
data analysis
intimate partner violence