Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford progeria syndrome.
Florian KöhlerFelix BormannGünter RaddatzJulian GutekunstSamuel CorlessTanja MuschAnke S LonsdorfSylvia ErhardtFrank LykoManuel Rodríguez-ParedesPublished in: Genome medicine (2020)
Taken together, our results strongly implicate epigenetic deregulation of LADs as an important and previously unrecognized feature of HGPS, which contributes to disease-specific gene expression. Therefore, they not only add a new layer to the study of epigenetic changes in the progeroid syndrome, but also advance our understanding of the disease's pathology at the cellular level.