Exosome-transmitted lncRNA PCGEM1 promotes invasive and metastasis in gastric cancer by maintaining the stability of SNAI1.

Hai-Yan Piao Shuai Guo Yue Wang Jun Zhang

Published in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2020)

LncRNA PCGEM1 was overexpressed in GC cells. And part of the PCGEM1 can be encapsulated into exosomes. These exosomes promoted invasion and migration of other GC cells. We considered PCGEM1 might act as a "scaffold" combined with SNAI1 and prompt the invasion and migration of GC.

Keyphrases

induced apoptosis
cell cycle arrest
mesenchymal stem cells
stem cells
cell migration
long non coding rna
endoplasmic reticulum stress
gas chromatography
cell death
signaling pathway
oxidative stress
high resolution
mass spectrometry
tandem mass spectrometry
liquid chromatography