The inflammatory kinase IKKα phosphorylates and stabilizes c-Myc and enhances its activity.

Bernhard MoserBernhard HochreiterJosé BasílioViola GleitsmannAnja PanhuberAlan Pardo-GarciaBastian HoeselManuel SalzmannUlrike ReschMamoona NoreenJohannes A Schmid

Published in: Molecular cancer (2021)

Our data imply that IKKα phosphorylates c-Myc on serines-67/71, thereby stabilizing it, leading to increased transcriptional activity, higher proliferation and decreased apoptosis.

Keyphrases

oxidative stress
signaling pathway
transcription factor
cell death
machine learning
artificial intelligence