18F-FDG brain PET hypometabolism in post-SARS-CoV-2 infection: substrate for persistent/delayed disorders?
Eric GuedjM MillionP DudouetH Tissot-DupontF BregeonS CammilleriD RaoultPublished in: European journal of nuclear medicine and molecular imaging (2020)
These preliminary findings reinforce the hypotheses of SARS-CoV-2 neurotropism through the olfactory bulb and the possible extension of this impairment to other brain structures. 18F-FDG PET hypometabolism could constitute a cerebral quantitative biomarker of this involvement. Post-viral cohort studies are required to specify the exact relationship between such hypometabolisms and the possible persistent disorders, especially involving cognitive or emotion disturbances, residual respiratory symptoms, or painful complaints.
Keyphrases
- pet ct
- sars cov
- positron emission tomography
- pet imaging
- respiratory syndrome coronavirus
- computed tomography
- resting state
- white matter
- cerebral ischemia
- high resolution
- functional connectivity
- subarachnoid hemorrhage
- depressive symptoms
- autism spectrum disorder
- density functional theory
- multiple sclerosis
- mass spectrometry
- blood brain barrier
- cerebral blood flow