Fibrinogen Depletion Coagulopathy Predicts Major Bleeding After Thrombolysis for Ischemic Stroke: A Multicenter Study.
Michele RomoliLaura VandelliGuido BigliardiMarcello NaccaratoJessica MollerMaurizio BalestrinoFabrizio GiammelloMauro GentileMaria Luisa Dell'AcquaPaolo ManganottiStefano ForlivesiMaurizio MelisLivio PicchettoFrancesca RosafioGiovanni FurlanisStefania TestoniValeria PirasLaura MalfattoRosa Fortunata MusolinoIlario ScaliStefania MaffeiLudovica MigliaccioTommaso TrentiRita ManciniMarco MariettaVanda RandiStefano MelettiAndrea ZiniPublished in: Stroke (2022)
Fibrinogen depletion significantly increases the risk of sICH and major bleeding after IVT for acute ischemic stroke. Fibrinogen depletion represents an independent risk factor for bleeding, and routine assessment could be considered to stratify the risk of ICH. Trials on early fibrinogen repletion are needed to investigate mitigation of bleeding risk.