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Altered cerebellar and caudate gray-matter volumes and structural covariance networks preceding dual cognitive and mobility impairments in older people.

Pei-Lin LeeKun-Hsien ChouWei-Ju LeeLi-Ning PengLiang-Kung ChenChing-Po LinChih-Kuang LiangChih-Ping Chung
Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
Neuroanatomic precursors of dual cognitive and mobility impairments are identified. Cerebellar GMV reductions and increased right caudate GMV precede the onset of PCDS. Altered cerebellum- and caudate-based SCNs drive PCDS transformation. This research establishes a foundation for understanding PCDS as a specific dementia syndrome.
Keyphrases
  • mild cognitive impairment
  • cognitive impairment
  • case report