Caffeic acid phenethyl ester suppresses androgen receptor signaling and stability via inhibition of phosphorylation on Ser81 and Ser213.

Ying-Yu KuoChieh HuoChing-Yu LinHui-Ping LinJai-Shin LiuWen-Ching WangChuang-Rung ChangChin-Pin Chuu

Published in: Cell communication and signaling : CCS (2019)

Our results suggested that CAPE treatment reduced AR stability and AR transcriptional activity in PCa cells, implying the possibility of using CAPE as a treatment for advanced PCa.

Keyphrases

south africa
induced apoptosis
gene expression
signaling pathway
protein kinase
smoking cessation
heat stress