Urine-based multi-omic comparative analysis of COVID-19 and bacterial sepsis-induced ARDS.
Richa BatraRie UniOleh M AkchurinSergio Alvarez-MulettLuis G Gómez-EscobarEdwin PatinoKatherine L HoffmanWill SimmonsWilliam WhalenKelsey ChetnikMustafa BuyukozkanElisa BenedettiKarsten SuhreEdward SchenckSoo Jung ChoAugustine M K ChoiFrank SchmidtMary E ChoiJan KrumsiekPublished in: Molecular medicine (Cambridge, Mass.) (2023)
In summary, our results provide evidence for significant molecular differences in ARDS patients from different etiologies and a potential synergy of extracellular matrix molecules, inflammation, and mitochondrial dysfunction in ARDS pathogenesis. The proteomic mortality signature should be further investigated in future studies to develop prediction models for COVID-19 patient outcomes.
Keyphrases
- extracellular matrix
- acute respiratory distress syndrome
- coronavirus disease
- sars cov
- extracorporeal membrane oxygenation
- mechanical ventilation
- end stage renal disease
- ejection fraction
- newly diagnosed
- intensive care unit
- chronic kidney disease
- cardiovascular events
- acute kidney injury
- peritoneal dialysis
- risk factors
- cardiovascular disease
- type diabetes
- high resolution
- drug induced