Clinical significance of the bronchodilator response in children with severe asthma.
Andrea M CoverstoneLeonard B BacharierBradley S WilsonAnne M FitzpatrickWilliam Gerald TeagueWanda PhipatanakulSally E WenzelBenjamin M GastonEugene R BleeckerWendy C MooreSima RamratnamNizar N JarjourNgoc P LyJohn V FahyDavid T MaugerKenneth B SchechtmanHuiqing Yin-DeClueJonathan S BoomerMario CastroPublished in: Pediatric pulmonology (2019)
Lung function, that is FEV1 % predicted, is a predictor of BD response in children with asthma. Additionally, smoke exposure, higher FeNO or IgE level, and low peripheral blood neutrophils are associated with a greater likelihood of BD reversibility. BD response can identify a phenotype of pediatric asthma associated with low lung function and poor asthma control.