Additive effects of variants of unknown significance in replication repair-associated DNA polymerase genes on mutational burden and prognosis across diverse cancers.
Jieer YingLin YangJiani C YinGuojie XiaMinyan XingXiaoxi ChenJiaohui PangYong WuHua BaoXue WuYang ShaoLingjun ZhuXiangdong ChengPublished in: Journal for immunotherapy of cancer (2022)
Our results demonstrate the pathogenicity and additive prognostic value of POL VUS and DDR pathway gene alterations and suggest that genetic testing may be warranted in patients with diverse solid tumors.