The Relationship between Cancer and Dementia: An Updated Review.
Yung-Shuo KaoCheng-Chang YehYi-Fang ChenPublished in: Cancers (2023)
The risk of cancer and dementia increases with age, raising complex questions about whether it is appropriate to continue cancer treatment in older patients. There is emerging research suggesting the association between cancer and dementia. However, the mechanistic underpinnings are still under investigation. Progress has already been made toward understanding the cognitive effects associated with cancer therapy. Such associations raise awareness about the need to establish better prevention methods and early screening in clinical practice. Additionally, recent studies have suggested possible therapeutic strategies for better preserving cognitive function and reducing the risk for dementia before patients start cancer treatment. We review the current literature and summarize the incidence and mechanisms of cognitive impairment in patients with lung cancer, breast cancer, head and neck cancer, gastric cancer, prostate cancer, colorectal cancer, and brain tumor/brain metastasis following different kinds of therapies. Possible risk factors are suggested to identify the early onset of cognitive changes in cancer patients and provide more insight into the pathophysiological process of dementia.
Keyphrases
- cognitive impairment
- mild cognitive impairment
- early onset
- papillary thyroid
- prostate cancer
- risk factors
- squamous cell
- cancer therapy
- clinical practice
- end stage renal disease
- systematic review
- late onset
- childhood cancer
- ejection fraction
- drug delivery
- chronic kidney disease
- lymph node metastasis
- newly diagnosed
- radical prostatectomy
- young adults
- peritoneal dialysis
- blood brain barrier
- patient reported outcomes
- prognostic factors
- cerebral ischemia
- patient reported