Mild Chronic Colitis Triggers Parkinsonism in LRRK2 Mutant Mice Through Activating TNF-α Pathway.

Chin-Hsien LinHan-Yi LinEn-Pong HoYi-Ci KeMei-Fang ChengChyng-Yann ShiueChi-Han WuPeng-Hsiang LiaoAngela Yu-Huey HsuLi-An ChuYa-Ding LiuYa-Hui LinYi-Cheng TaiChia-Tung ShunHan-Mo ChiuMing-Shiang Wu

Published in: Movement disorders : official journal of the Movement Disorder Society (2021)

Our findings demonstrate that chronic colitis promotes parkinsonism in genetically susceptible mice and TNF-α plays a detrimental role in the gut-brain axis of PD. © 2021 International Parkinson and Movement Disorder Society.

Keyphrases

drug induced
rheumatoid arthritis
high fat diet induced
wild type
parkinson disease
signaling pathway
white matter
resting state
insulin resistance
adipose tissue
functional connectivity
skeletal muscle