Methotrexate and theaflavin-3, 3'-digallate synergistically restore the balance between apoptosis and autophagy in synovial fibroblast of RA: an ex vivo approach with cultured human RA FLS.

Sanchaita MisraAniruddha BagchiAvik SarkarSougata NiyogiDipanjan BhattacharjeeSulagna ChatterjeeSumantro MondalArghya ChattopadhyayAyindrila SahaSudipta ChatterjeePradyot SinhamahapatraPartha ChakrabartiMitali ChatterjeeAlakendu Ghosh

Published in: Inflammopharmacology (2021)

Disruption in homeostasis between apoptosis and autophagy in fd-FLS might be an underlying phenomenon in the progression of pathophysiology in RA. Co-administration of MTX + TF3 successfully restored the homeostasis by inducing apoptosis.

Keyphrases

endoplasmic reticulum stress
oxidative stress
cell death
cell cycle arrest
rheumatoid arthritis
endothelial cells
disease activity
signaling pathway
ankylosing spondylitis
high dose
interstitial lung disease
low dose
pi k akt
cell proliferation