Epstein-Barr Virus in the Cerebrospinal Fluid and Blood Compartments of Patients With Multiple Sclerosis and Controls.
Joonas LehikoinenKatariina NurmiMari AinolaJonna ClancyJanne K NieminenLilja JanssonHanna VauhkonenAntti VaheriTeemu SmuraSini M LaaksoKari K EklundPentti J TienariPublished in: Neurology(R) neuroimmunology & neuroinflammation (2024)
EBV-DNA is equally detectable in the CSF cells of both patients with MS and controls with ddPCR, and the probabilistic approach indicates that the true positivity rate approaches 100% in EBV-positive individuals. The proportion of EBV-positive B cells seems higher than previously estimated.