Molecular heterogeneity and commonalities in pancreatic cancer precursors with gastric and intestinal phenotype.

Sven-Thorsten LiffersLaura GodfreyLisa FrohnLena HaeberleAslihan YavasRita VesceWolfgang GoeringFriederike V OpitzNickolas StoeckleinWolfram Trudo KnoefelAnna Melissa SchlitterGuenter KlöppelElisa EspinetAndreas TrumppJens T SivekeIrene Esposito

Published in: Gut (2022)

PDAC precursors with gastric and intestinal phenotype are heterogeneous in terms of morphology, genetic and epigenetic profile. This heterogeneity is related to a different cell identity and, possibly, to a different aetiology.

Keyphrases

single cell
dna methylation
gene expression
cell therapy
stem cells
mesenchymal stem cells