Genetic Evaluation of A Nation-Wide Dutch Pediatric DCM Cohort: The Use of Genetic Testing in Risk Stratification.
Marijke H van der MeulenJohanna C HerkertSusanna L den BoerGideon J du Marchie SarvaasNico A BlomArend D J Ten HarkelJohannes M P J BreurLukas Augustinus Johannes RammelooRonald B TankeCarlo L MarcelisIngrid M B H van de LaarJudith M A VerhagenRonald H Lekanne DeprezDaniela Q C M Barge-SchaapveldAnnette F BaasArjan SammaniImke ChristiaansJ Peter van TintelenMichiel DalinghausPublished in: Circulation. Genomic and precision medicine (2022)
Genetic testing is a valuable tool for predicting prognosis in children with dilated cardiomyopathy, with carriers of a likely pathogenic or pathogenic variant having a worse prognosis overall. Genetic testing should be incorporated in clinical work-up of all children with dilated cardiomyopathy regardless of presumed disease pathogenesis.