Is 6-Shogaol an Effective Phytochemical for Patients With Lower-risk Myelodysplastic Syndrome? A Narrative Review.
Soo Liang OoiRon CampbellSok Cheon PakTerry GolombickArumugam ManoharanRaj RamakrishnaVladimir BadmaevJanet SchlossPublished in: Integrative cancer therapies (2022)
Myelodysplastic syndrome (MDS) evolves due to genomic instability, dysregulated signaling pathways, and overproduction of inflammatory markers. Reactive oxygen species contribute to the inflammatory response, which causes gene damage, cellular remodeling, and fibrosis. MDS can be a debilitating condition, and management options in patients with MDS aim to improve cytopenias, delay disease progression, and enhance quality of life. High serum ferritin levels, a source of iron for reactive oxygen species production, correlate with a higher risk of progression to acute myeloid leukemia, and iron overload is compounded by blood transfusions given to improve anemia. 6-shogaol is a natural phenolic compound formed when ginger is exposed to heat and/or acidic conditions, and it has been shown to possess anti-tumor activity against leukemia cell lines and antioxidant effects. This narrative review assessed the potential benefits of this phytochemical in lower-risk MDS patients through examining the current evidence on the pharmacological and therapeutic properties of ginger and 6-shogaol.
Keyphrases
- genome wide identification
- reactive oxygen species
- acute myeloid leukemia
- iron deficiency
- inflammatory response
- end stage renal disease
- chronic kidney disease
- oxidative stress
- ejection fraction
- newly diagnosed
- signaling pathway
- prognostic factors
- peritoneal dialysis
- lipopolysaccharide induced
- copy number
- toll like receptor
- anti inflammatory
- acute lymphoblastic leukemia
- climate change
- genome wide
- dna methylation
- immune response
- induced apoptosis
- liver fibrosis