PCSK9 increases vulnerability of carotid plaque by promoting mitochondrial dysfunction and apoptosis of vascular smooth muscle cells.

Ran XuTianhua LiJichang LuoXiao ZhangTao WangYabing WangYan MaBin YangJinzhu JiaAdam A DmytriwWenjing LiLingyun Jia

Published in: CNS neuroscience & therapeutics (2024)

Our findings demonstrated that PCSK9 induced morphology-related mitochondrial dysfunction and apoptosis of VSMCs, which may be related to increased vulnerability of carotid plaque.

Keyphrases

vascular smooth muscle cells
oxidative stress
climate change
endoplasmic reticulum stress
angiotensin ii
coronary artery disease
cell cycle arrest
cell death
high glucose
drug induced
signaling pathway
cell proliferation
low density lipoprotein
stress induced