Dysprosium and Holmium Vanadate Nanoprobes as High-Performance Contrast Agents for High-Field Magnetic Resonance and Computed Tomography Imaging.
Elisabet Gómez-GónzalezNuria O NúñezCarlos CaroMaría Luisa García-MartínYilian Fernández-AfonsoJesús Martínez de la FuenteMarcin BalcerzykManuel OcañaPublished in: Inorganic chemistry (2020)
We describe a wet chemical method for the synthesis of uniform and well-dispersed dysprosium vanadate (DyVO4) and holmium vanadate (HoVO4) nanoparticles with an almost spherical shape and a mean size of ∼60 nm and their functionalization with poly(acrylic acid). The transverse magnetic relaxivity of both systems at 9.4 T is analyzed on the basis of magnetic susceptibility and magnetization measurements in order to evaluate their potential for application as high-field MRI contrast agents. In addition, the X-ray attenuation properties of these systems are also studied to determine their capabilities as computed tomography contrast agent. Finally, the colloidal stability under physiological pH conditions and the cytotoxicity of the functionalized NPs are also addressed to assess their suitability for bioimaging applications.
Keyphrases
- contrast enhanced
- magnetic resonance
- computed tomography
- dual energy
- magnetic resonance imaging
- molecularly imprinted
- single molecule
- high resolution
- positron emission tomography
- diffusion weighted imaging
- quantum dots
- benign prostatic hyperplasia
- fluorescence imaging
- photodynamic therapy
- living cells
- mass spectrometry
- climate change
- tandem mass spectrometry
- solid phase extraction