Luciferase-Rose Bengal conjugates for singlet oxygen generation by bioluminescence resonance energy transfer.
Seonghoon KimHyeongChan JoMijeong JeonMyung-Gyu ChoiSei Kwang HahnSeok-Hyun YunPublished in: Chemical communications (Cambridge, England) (2018)
Conjugates of Rose Bengal and Renilla luciferase generated singlet oxygen upon binding with coelenterazine via bioluminescence resonance energy transfer (BRET). Since the applications of conventional PDT have been limited to superficial lesions due to the limited light penetration in tissue, BRET activated PDT which does not require external light illumination may overcome the limitations of conventional PDT.