Biomimetic Synthesis of Lankacidin Antibiotics.

Kuan ZhengDefeng ShenRan Hong

Published in: Journal of the American Chemical Society (2017)

We devised short syntheses of lankacidinol and lankacyclinol that feature biomimetic Mannich macrocyclization. The modular construction of the carbon framework of these compounds is amenable to rapid structural diversification for the development of antibiotic and antitumor agents.

Keyphrases

tissue engineering
machine learning
deep learning
loop mediated isothermal amplification
neural network
sensitive detection