Mesenchymal Stem Cell-Derived Exosomes Ameliorated Diabetic Nephropathy by Autophagy Induction through the mTOR Signaling Pathway.
Nesrine EbrahimInas A AhmedNoha I HussienArigue A DessoukyAyman Samir FaridAmal M ElshazlyOla MostafaWalaa Bayoumie El GazzarSafwa M SorourYasmin SeleemAhmed M HusseinDina SabryPublished in: Cells (2018)
We conclude that autophagy induction by exosomes could attenuate DN in a rat model of streptozotocin-induced diabetes mellitus.
Keyphrases
- diabetic nephropathy
- mesenchymal stem cells
- signaling pathway
- diabetic rats
- oxidative stress
- cell death
- endoplasmic reticulum stress
- umbilical cord
- pi k akt
- stem cells
- induced apoptosis
- bone marrow
- epithelial mesenchymal transition
- high glucose
- cell proliferation
- high fat diet
- endothelial cells
- insulin resistance
- glycemic control