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Sex differences of NF-κB-targeted therapy for mitigating osteoporosis associated with chronic inflammation of bone.

Masakazu ToyaJunichi KushiokaHuaishuang ShenTakeshi UtsunomiyaHirohito HirataMasanori TsubosakaQi GaoSimon Kwoon-Ho ChowNing ZhangStuart Barry Goodman
Published in: Bone & joint research (2024)
We demonstrated that NF-κB decoy ODN increased osteogenesis in male mice and decreased bone resorption activity in both sexes in preclinical models of chronic inflammation. NF-κB signalling could be a therapeutic target for chronic inflammatory diseases involving bone, especially in males.
Keyphrases
  • oxidative stress
  • bone mineral density
  • signaling pathway
  • lps induced
  • bone loss
  • bone regeneration
  • postmenopausal women
  • pi k akt
  • nuclear factor
  • body composition
  • stem cells
  • cell proliferation
  • mesenchymal stem cells