Evaluation of direct intramural injection to the bladder wall as a method for developing orthotopic tumor models.
Masoud BitarafSamad MuhammadnejadAshkan AzimzadehSaman Behboodi TanourloueeErfan AminiMasoumeh Majidi ZolbinAbdol-Mohammad KajbafzadehPublished in: Animal models and experimental medicine (2022)
Direct intramural injection is a rapid, reliable, and reproducible method for developing orthotopic models of bladder cancer. It can be done on both male and female mice and only requires readily available surgical tools. However, needle track can result in cell spillage and peritoneal tumors.