The C-terminal region of the oxidoreductase MIA40 stabilizes its cytosolic precursor during mitochondrial import.

Lena Maria MurschallAnne GerhardsThomas MacVicarEsra PekerLidwina HasbergStephan WawraThomas LangerJan Riemer

Published in: BMC biology (2020)

Our data suggest that the MIA40 precursor contains the stabilizing information to allow for postranslational import of sufficient amounts of MIA40 for full functionality of the essential disulfide relay. We thereby provide for the first time mechanistic insights into the determinants controlling cytosolic surveillance of IMS precursor proteins.

Keyphrases

public health
oxidative stress
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