Effect of Supplemental Oxygen on Blood Pressure in Obstructive Sleep Apnea (SOX). A Randomized Continuous Positive Airway Pressure Withdrawal Trial.
Chris D TurnbullDushendree SenMalcolm KohlerNayia PetousiJohn R StradlingPublished in: American journal of respiratory and critical care medicine (2019)
Supplemental oxygen virtually abolished the rise in morning BP during CPAP withdrawal. Supplemental oxygen substantially reduced intermittent hypoxia, but had a minimal effect on markers of arousal (including AHI), subjective sleepiness, or objective sleepiness. Therefore intermittent hypoxia, and not recurrent arousals, appears to be the dominant cause of daytime increases in BP in OSA.
Keyphrases
- obstructive sleep apnea
- positive airway pressure
- sleep apnea
- blood pressure
- endothelial cells
- high intensity
- clinical trial
- stem cells
- study protocol
- transcription factor
- heart rate
- sleep quality
- hypertensive patients
- metabolic syndrome
- phase iii
- depressive symptoms
- type diabetes
- physical activity
- adipose tissue
- weight loss
- skeletal muscle