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Germ Cell Tumor of the Testis: Lethal Subtypes of a Curable Cancer.

Jamaal C JacksonDarren SanchezAndrew C JohnsMatthew T CampbellAhmet Murat AydinNeriman GokdenSanjay MaraboyinaJason L MuesseJohn F WardLouis L PistersNiki M ZachariasCharles C GuoShi-Ming Tu
Published in: Journal of clinical medicine (2024)
Germ cell tumor of the testis (GCT) is a curable cancer even when it is widely metastatic; however, outcomes can differ based on tumor histology. Chemo-resistance in certain phenotypes, such as teratoma and yolk sac tumor, contributes to poor clinical outcomes in some patients with GCT. Despite this resistance to S-YSTemic therapy, many of these tumor subtypes remain amenable to surgical resection and possible cure. In this study, we report on a series of seven patients highlighting two chemo-resistant subtypes of nonseminomatous germ cell tumor (NSGCT), sarcomatoid yolk sac tumor (S-YST), and epithelioid trophoblastic tumor (ETT) for which early resection rather than additional salvage chemotherapy or high-dose intense chemotherapy might provide a superior clinical outcome and enhance cure rate.
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