Knockdown of TRPM7 prevents tumor growth, migration, and invasion through the Src, Akt, and JNK pathway in bladder cancer.
Eun Hye LeeSo Young ChunBomi KimBo Hyun YoonJun Nyung LeeBum Soo KimEun Sang YooSangkyu LeePhil Hyun SongTae Gyun KwonYun Sok HaPublished in: BMC urology (2020)
Our data reveal that TRPM7 regulates the migration and invasion of T24 and UMUC3 cells via the Src, Akt, and JNK signaling pathway. Therefore, TRPM7 suppression could be a potential treatment for BC patients.
Keyphrases
- signaling pathway
- induced apoptosis
- pi k akt
- epithelial mesenchymal transition
- cell cycle arrest
- end stage renal disease
- tyrosine kinase
- endoplasmic reticulum stress
- ejection fraction
- cell proliferation
- cell death
- newly diagnosed
- oxidative stress
- genome wide
- big data
- single cell
- combination therapy
- smoking cessation