Performance of model-based multifactor dimensionality reduction methods for epistasis detection by controlling population structure.
Fentaw AbegazFrançois Van LishoutJestinah M Mahachie JohnKridsadakorn ChiachoompuArchana BhardwajDiane DurouxElena S GusarevaZhi WeiHakon HakonarsonKristel Van SteenPublished in: BioData mining (2021)
We demonstrate through extensive simulation studies the effect of various degrees of genetic population structure and relatedness on epistasis detection and propose appropriate remedial measures based on linear and nonlinear sample genetic similarity.