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Dendritic poly-chelator frameworks for multimeric bioconjugation.

Dominik ReichAlexander WurzerMartina WirtzVeronika StieglerPhilipp SpatzJulia PollmannHans-Jürgen WesterJohannes Notni
Published in: Chemical communications (Cambridge, England) (2018)
Starting from multifunctional triazacyclononane-triphosphinate chelator cores, dendritic molecules with the ability to bind metal ions within their framework were synthesized. A cooperative interaction of the chelator cages resulted in a markedly increased affinity towards 67/68GaIII. A hexameric PSMA inhibitor conjugate with high affinity (IC50 = 1.2 nM) and favorable in vivo PET imaging properties demonstrated practical applicability. The novel scaffolds are useful for synthesis of structurally well-defined multimodal imaging probes or theranostics.
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