Cumulative Detection of Anal High-Grade Squamous Intraepithelial Lesions Over 2-Year Follow-up in Men Who Have Sex With Men Living With Human Immunodeficiency Virus in France.
Jean-Damien CombesJean-Michel DidelotSylvie RadenneOlivia Zaegel-FaucherAnne-Carole LesageLaurent SiproudhisLionel PirothLucie MarchandIsabelle HeardNadia HoyeauSébastien HennoTeresa M DarraghCatharina J AlbertsGary M CliffordIsabelle Etienneynull nullPublished in: The Journal of infectious diseases (2024)
We assessed cumulative detection and determinants of anal high-grade squamous intraepithelial lesions (HSILs) in men who have sex with men living with human immunodeficiency virus and who underwent 3 visits over 2 years, with cytology and high-resolution anoscopy, within the ANRS-EP57-APACHES study. The cumulative HSIL detection rate was 33% (134 of 410), of which 48% HSILs were detected at baseline. HSIL detection varied considerably by center (from 13% to 51%). The strongest HSIL determinants were baseline human papillomavirus 16 (adjusted odds ratio, 8.2; 95% confidence interval, 3.6-18.9) and p16/Ki67 (4.6 [2.3-9.1]). Repeated annual cytology and high-resolution anoscopy improved HSIL detection but did not fully compensate for between-center heterogeneity.
Keyphrases
- high grade
- human immunodeficiency virus
- men who have sex with men
- low grade
- hiv positive
- hiv testing
- high resolution
- hepatitis c virus
- antiretroviral therapy
- loop mediated isothermal amplification
- label free
- real time pcr
- hiv infected
- mass spectrometry
- squamous cell carcinoma
- radiation therapy
- hiv aids
- fine needle aspiration