Hyaluronan in Adipose Tissue, Metabolic Inflammation, and Diabetes: Innocent Bystander or Guilty Party?
Krzysztof DrygalskiSimon LecoutreKarine ClémentIsabelle DugailPublished in: Diabetes (2023)
Hyaluronic acid, or hyaluronan (HA), is a nonsulfated glucosaminoglycan that has long been recognized for its hydrophilic properties and is widely used as a dermal filler. Despite much attention given to the study of other extracellular matrix (ECM) components, in the field of ECM properties and their contribution to tissue fibroinflammation, little is known of HA's potential role in the extracellular milieu. However, recent studies suggest that it is involved in inflammatory response, diet-induced insulin resistance, adipogenesis, and autoimmunity in type 1 diabetes. Based on its unique physical property as a regulator of osmotic pressure, we emphasize underestimated implications in adipose tissue function, adipogenesis, and obesity-related dysfunction.
Keyphrases
- insulin resistance
- extracellular matrix
- hyaluronic acid
- adipose tissue
- high fat diet induced
- type diabetes
- inflammatory response
- glycemic control
- high fat diet
- oxidative stress
- polycystic ovary syndrome
- metabolic syndrome
- skeletal muscle
- cardiovascular disease
- liquid chromatography
- transcription factor
- lipopolysaccharide induced
- physical activity
- mass spectrometry
- weight gain
- body mass index
- high resolution
- solid phase extraction