Brain Metabolic Profile in Presymptomatic GRN Carriers Throughout a 5-Year Follow-up.
Dario SaracinoLeila SellamiHugo BonifaceMarion HouotMélanie Pélégrini-IssacAurélie FunkiewiezDaisy RinaldiMaxime LocatelliCarole AzuarValérie Causse-LemercierAlice JaillardFlorence PasquierMathieu ChastanDavid WallonAnne HitzelJeremie ParienteAmandine PallardyClaire Boutoleau-BretonnièreEric GuedjMira DidicRaffaella MigliaccioAurélie KasMarie-Odile HabertIsabelle Le Bernull nullPublished in: Neurology (2022)
disease. Due to the STS involvement in the perception of facially communicated cues, it is likely that its dysfunction contributes to social cognition deficits characterizing FTD. Overall, our study highlights brain metabolic changes as an early disease-tracking biomarker, and proposes annualized percent decrease as a metric to monitor therapeutic response in forthcoming trials.