Single-Cell-Derived Primary Rectal Carcinoma Cell Lines Reflect Intratumor Heterogeneity Associated with Treatment Response.
Rüdiger BraunLena AnthuberDaniela HirschDarawalee WangsaJustin LackNicole E McNeilKerstin Heselmeyer-HaddadIrianna TorresDanny WangsaMarkus A BrownAnthony TubbsNoam AuslanderEdward Michael GertzPhilip R BrauerMargaret C CamDan L SackettJens K HabermannAndre NussenzweigEytan RuppinZhongqiu ZhangDaniel W RosenbergThomas RiedPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
Our model system of patient-derived SCDCLs provides evidence for the critical role of ITH for treatment response in patients with rectal cancer and shows that distinct genetic aberration profiles are associated with treatment response. We identified specific pathways as the molecular basis of treatment response of individual clones, which could be targeted in resistant subclones of a heterogenous tumor.