Physiologically based pharmacokinetic modelling of acute digoxin toxicity and the effect of digoxin-specific antibody fragments.

Lucy M Bracken Betty S H Chan Nicholas Alan Buckley

Published in: Clinical toxicology (Philadelphia, Pa.) (2018)

Compared to conventional two-compartment modelling, PBPK modelling is superior in generating realistic simulations of acute digoxin toxicity and the response to digoxin-Fab. Simulation capacity provides realistic, continuous data which has the potential to substantiate alternative, less expensive, and safer digoxin-Fab dosing strategies for the treatment of acute digoxin toxicity.

Keyphrases

liver failure
respiratory failure
drug induced
oxidative stress
aortic dissection
risk assessment
climate change