Immune checkpoint inhibitor-induced hepatitis injury: risk factors, outcomes, and impact on survival.

Abdul MiahGabriel TinocoSongzhu ZhaoLai WeiAndrew JohnsSandip PatelMingjia LiMadison GroganGabrielle LopezMarium HusainRebecca HoydKhalid MumtazAlexa MearaErin M BertinoKari KendraDaniel SpakowiczGregory A OttersonCarolyn J PresleyDwight H Owen

Published in: Journal of cancer research and clinical oncology (2022)

Female sex, combination immunotherapy, and the first line of immunotherapy were associated with ICIH. Patients with ICIH had improved clinical survival compared to those that did not develop ICIH. There is a need for prospective further studies to confirm our findings.

Keyphrases

risk factors
free survival
high glucose
drug induced
metabolic syndrome
oxidative stress
skeletal muscle
weight loss